[Sensitivity and
resistance to antimicrobial agents ESBL-producing and not producing ESBL
strains of E. coli in patients with urinary tract infection.]
Abstract
As a result of the conducted researches it is
shown that 44.1% of urinary tract infections (UTIS) caused by E. coli are
accounted for by producers of beta-lactamase of the extended spectrum of action
(ESBL). Associated resistance to fluoroquinolones and co-trimoxazole was found
in 93.3% of BLRS-producing E. coli strains. All studied strains regardless of
ESBL production were sensitive to imipenem, the majority showed sensitivity to
ertapenem, gentamicin and resistance to doxycycline. Not producing ESBL strains
of E. coli were sensitive to fosfomycin. Comparison of data obtained during
testing of isolated cultures on ESBL, study of their sensitivity and resistance
to beta-lactams (amoxicillin/clavulanate, ceftazidime, ceftriaxone, cefotaxime,
imipenem) indicates the need to test isolates for AmpC products. To this end,
during the screening test for ESBL and the method of «double disks», along with
cephalosporins of III generation, it is necessary to use a phenotypic test for
sensitivity to cefepime. The use of test results of E. coli isolates isolated
from patients with UTIS for the production of ESBL, ampC enzymes, carbapenemase
and sensitivity to AMP will improve the effectiveness of antimicrobial therapy
and will help to curb the formation and spread of antimicrobial-resistan
strains.
https://www.blogger.com/blogger.g?blogID=7133329557719394967#editor/target=post;postID=8147596956561309038
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